Design of a Multicomponent Peptide-Woven Nanocomplex for Delivery of siRNA
نویسندگان
چکیده
منابع مشابه
Design of a Multicomponent Peptide-Woven Nanocomplex for Delivery of siRNA
We developed and tested a multicomponent peptide-woven siRNA nanocomplex (PwSN) comprising different peptides designed for efficient cellular targeting, endosomal escape, and release of siRNA. To enhance tumor-specific cellular uptake, we connected an interleukin-4 receptor-targeting peptide (I4R) to a nine-arginine peptide (9r), yielding I4R-9r. To facilitate endosomal escape, we blended endos...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0118310